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Federal (FBISE) · Chapter test · Free

2nd Year Biology Chapter 12 Test12. Structural Biology and Computational Biology

30 marks · 40 minutes · 21 questions. Covers: 12. Structural Biology and Computational Biology.

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2nd Year Biology Chapter 12 Test

2nd Year · Biology · Federal (FBISE)

Name: ____________Roll No: ________Class/Section: ________Date: ________Total marks: 30Time: 40 minutes

Q1. Multiple choice questions (Attempt all · 10 × 1 = 10)

  1. The two types of homology discussed in this section are:
    1. Genetic and metabolic homology
    2. Sequence and structure homology
    3. Plant and animal homology
    4. Behavioral and ecological homology
  2. Computational biology contributes to personalized treatments based on:
    1. Blood group only
    2. Random selection
    3. Individual genetic profiles
    4. Environmental conditions only
  3. Which molecule’s structural homology is shown in Fig. 12.5 for different mammals?
    1. Hemoglobin
    2. Myoglobin
    3. Insulin
    4. Keratin
  4. Which analogy is used to explain the relationship between biomolecule structure and function?
    1. Plant and sunlight
    2. Key and lock
    3. Teacher and student
    4. Pen and paper
  5. Homology refers to:
    1. Differences in unrelated species
    2. Similarity of structure
    3. Random mutations only
    4. Artificial selection in plants
  6. Which step reconstructs the 3D electron density map of the biomolecule?
    1. X-ray diffraction
    2. Model building and refinement
    3. Data collection and processing
    4. Crystallization
  7. There are more than 200 types of cancers. Proper treatment of a specific cancer requires personalized medicines because each cancer has a:
    1. different name
    2. different effect on each person
    3. specific cell surface marker
    4. different set of symptoms
  8. X-ray crystallography is mainly used to determine:
    1. Soil fertility
    2. 3D structure of biomolecules
    3. Climate change patterns
    4. Plant anatomy
  9. The Protein Data Bank provide information about:
    1. all molecules
    2. all proteins
    3. all enzymes
    4. all biomolecules
  10. Structural biology is mainly concerned with the study of:
    1. Plant anatomy
    2. Animal physiology
    3. 3D structure
    4. Ecology

Q2. Short questions (Attempt any 6 of 8 · 6 × 2 = 12)

  1. What role does structural biology play in advancing biotechnology?
  2. Which biological molecules are involved in structural homology?
  3. If you want to study the structure of pepsin enzyme, what will you do?
  4. When was the PDB established?
  5. Mention any two techniques used in structural biology.
  6. How does the structure of a biomolecule determine its function?
  7. What is the purpose of the crystallization step in X-ray crystallography?
  8. Define computational biology.

Q3. Long questions (Attempt any 2 of 3 · 2 × 4 = 8)

  1. Explain the steps of X-ray crystallography in detail.
  2. Differentiate between sequence and structural homology.
  3. Describe the steps of X-ray crystallography.